Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling
Highlights•Astrocyte processes reduce contact with synapses before synapse removal by microglia•Microglia-de…
Highlights•Astrocyte processes reduce contact with synapses before synapse removal by microglia•Microglia-de…
Highlights•Erythroblast island (EBI) macrophages are recruited to the bone metastatic niche•EBI macrophages …
AbstractAs tissue resident macrophages of the central nervous system (CNS) parenchyma, microglia perform diver…
Macrophages sense deviation in intracellular pH as a mechanism to guide the control of inflammatory responses.…
Clodronate, also known as clodronic acid, is a synthetic bisphosphonate that plays a significant role in inhib…
Liposomes are closed spherical structures formed by self-assembly of lipids into bilayers (monolayers) and/or …
Clodronate liposomes are lipid-based nanoparticles that encapsulate clodronate, a bisphosphonate compound trad…
Trojan horse, huge hollow wooden horse constructed by the Greeks to gain entrance into Troy during the Trojan …
Intravenous injection(IV), the most common method of dosing clodronate liposomes; about half of all clodronate…
Healthy tissue may be damaged by the activity of immune cells working to eradicate infection. Hoagland et al. …
Intraperitoneal(IP) administration of liposomes employs a direct delivery technique where liposomes carrying t…
AbstractAs tissue resident macrophages of the central nervous system (CNS) parenchyma, microglia perform diver…
Intranasal /Inhalation delivery is a method of administering medicine by inhaling it through the nose. As we a…
Intratracheal injection(IT) is a medical technique for delivering a substance directly into the trachea, or wi…
Intrathecal/Intraventricular injection of clodronate liposomes is a specialized medical procedure that holds g…
Intradermal injection (i.d. or ID) of clodronate liposomes has been used for elucidating the immune mechanisms…
Subcutaneous administration(SC) is done by injecting drugs into the fatty tissues just beneath the skin, which…
Intramuscular injection (IM) is installing medications into the depth of specifically selected muscles. The bu…
Retro-orbital injection(RO) is an acceptable alternative to the tail vein injection route, with proper trainin…
Intratumoral delivery（ITM） of drug represents a compelling solution to directly address local barriers to tu…
Intra-articular(IA) administration of clodronate liposomes is a therapeutic approach that involves the targete…
Intravaginal administration(IVA) is a route of drug delivery that involves introducing medications directly in…
Intrabursal administration(IB) is a technique used to deliver drugs directly into the ovarian bursa, a fluid-f…
