Clodronate, also known as clodronic acid, is a synthetic bisphosphonate that plays a significant role in inhibiting bone resorption. While it is widely used in the treatment of conditions such as osteoporosis and metastatic bone disease, its pharmacological potential extends beyond skeletal health. 

Clodronate disodium tetrahydrate Chemical Structure

CAS No. : 88416-50-6

Synonym(s):

Clodronate, Disodium Salt, Clodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate

Molecular Weight: 360.92   

Formula: CH10Cl2Na2O10P2   

CAS No.: 88416-50-6   

Appearance: Solid   

Color: White to off-white

Clodronate exhibits immunomodulatory properties by inducing apoptosis in macrophages when delivered intracellularly. This characteristic is particularly advantageous in research settings, as it allows scientists to manipulate macrophage populations and explore their contributions to different biological processes, including inflammation, tissue repair, and immune response regulation.